The new, direct, target-specific oral anticoagulants
نویسندگان
چکیده
منابع مشابه
Novel antidotes for target specific oral anticoagulants
Target specific oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) are changing the landscape of anticoagulation. The major drawback is the absence of an effective antidote for severe bleedings and/or prior to procedures. Currently there are a few promising antidotes undergoing clinical trials. This review summarized the latest development in idarucizumab, andexanet alpha and...
متن کاملTarget-Specific Oral Anticoagulants—New Approaches in the Field of Oral Anticoagulation
Direct oral anticoagulants targeting specific coagulation factors have been introduced as alternatives to conventional anticoagulants for both prophylactic and therapeutic indications. They have succeeded in overcoming the limitations of vitamin K antagonists. Although the favourable efficacy and side-effect profiles compared to vitamin K antagonists is proven, there is significant concern abou...
متن کاملWill the new target-specific oral anticoagulants improve the treatment of venous thromboembolism?
The current treatment of venous thromboembolism (VTE, i.e. deep-vein thrombosis [DVT] and pulmonary embolism [PE]), is challenging because of the need for a two drug regimen, parenteral therapy, followed by an oral vitamin K antagonist (VKA). The former often requires hospitalisation or complex arrangements for outpatient administration. The latter is associated with the complexity of transitio...
متن کاملThe new oral anticoagulants.
Although their first application in clinical practice occurred in the 1940s, vitamin K antagonists remain the only form of oral anticoagulant medication approved for long-term use. Although the available vitamin K antagonists are highly effective for the prevention and/or treatment of most thrombotic disease, the significant interpatient and intrapatient variability in dose-response, the narrow...
متن کاملDosing of Target-Specific Oral Anticoagulants in Special Populations.
OBJECTIVE To review current literature for target-specific oral anticoagulants (TSOACs) and provide critical analysis for dosing recommendations in special population groups. DATA SOURCES A literature search was conducted in Medline (1996 to April week 2 2015) and Embase (1980 to 2015 week 16) using key terms dabigatran, rivaroxaban, apixaban, edoxaban, kidney diseases, liver diseases, elderl...
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ژورنال
عنوان ژورنال: Journal of Applied Hematology
سال: 2015
ISSN: 1658-5127
DOI: 10.4103/1658-5127.171993